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Frequent Asked Questions

  • SLVRGEN®
  • REGEN-D®
  • COLGEN
  • PROLYSE
1. What is SLVRGEN® and what is it indicated for?
  1. SLVRGEN® is a novel synergistic formulation consisting of recombinant human Epidermal Growth Factor (rhEGF) with Silver Sulfadiazine (SSD) and Chlorhexidine Gluconate (CHG). It is a topical gelused for faster healing of first- and second-degree burns.
2. How is the SLVRGEN® stored ?
  1. SLVRGEN® is stable at room temperature 250C. Keep SLVRGEN® out of the reach and sight of children.
3. What all precautions must be taken while using SLVRGEN® ?
  1. SLVRGEN® should not be applied if ➢ You are allergic to any of its components ➢ You are pregnant woman or a nursing mother ➢ You are an immunocompromised individual ➢ You are receiving immunosuppressive or immunostimulant medications.
  2. The burn wounds should be cleaned and SLVRGEN® cream should be applied over all the affected areas to a depth of 3 to 5 mm. • One technique is to apply the cream with a sterile gloved hand and/or sterile spatula. • Where necessary, the cream should be re-applied to the area from which it has been removed by patient activity. • SLVRGEN® should be applied at least every 24 hours.
4. Which technology is used in making SLVRGEN® ?
  1. SLVRGEN® is developed using Recombinant Human Epidermal Growth Factor (rhEGF),involved in mechanisms such as normal cell growth & wound healing.
Silver Sulfadiazine acts as antimicrobial and exhibits bactericidal property & is effective againstyeast. Chlorhexidine Gluconate has antiseptic & antibacterial effects. It alters protein structure and configuration.
5. Why use SLVRGEN® ?
  1. The conventional SSD usage delays wound healing process by absorption of silver from burn wounds leading to cytotoxicity and bacterial resistance. The cytotoxic property of SSD in retarding the wound healing can be reversed with the addition of rhEGF. SLVRGEN® synergistically plays a vital role in controlling infection & also promoting fast wound healing.
6. How is SLVRGEN® more cost effective than any other similar product ?
  1. SLVRGEN® is cost effective in comparison with other commercially available topical gels as it significantly decreases the time of burn wound closure, follow-up visits & number of tubes required.
1. What is REGEN-D® 60 and how is it used ?
  1. REGEN-D®60 is developed from recombinant human epidermal growth factor (rhEGF). An epidermal growth factor is a small mitogenic protein that is involved in mechanisms such as normal cell growth, wound healing, and reduces the healing time.It is a topical gel used forfirst- and second-degree burns& donor site skin grafts.
2. What is REGEN-D® 150 and what are its use ?
  1. Regen-D® 150(recombinant human epidermal growth factor) is a topical gel used for faster healing of Diabetic foot ulcers, Bedsores(Pressure ulcers), Venous leg ulcers.rhEGFs enhances burn wound healing process by reducing the healing time drastically over the natural course, leaving minimal scars with quality healing.
3. How is REGEN-D® 60 AND 150 stored ?
  1. Keep Regen-D®150 out of the reach and sight of children. Store Regen-D® 150 at room temperature (25°C). Do not use Regen-D® 150 after the expiry date (EXP) which is stated on the package containing the tube.
  2. Keep Regen-D® 60 out of the reach and sight of children. Regen-D® 60 is stable at room temperature. Do not freeze. Do not use Regen-D® 60 after the expiry date (EXP) which is stated on the package containing the tube.
4. How is REGEN-D® 60 different from REGEN-D® 150 ?
  1. REGEN-D® 60 is composed of 60 µg of rhEGF & REGEN-D® 150 is developed from150 µg of rhEGF. The indications for both the products are different. REGEN-D® 60 is indicated for 1st& 2nd degree burns and donor site skin grafts. REGEN-D® 150 is a topical gel used for diabetic foot ulcers, bed sores (pressure ulcers) and venous leg ulcers.
5. What are the advantages of rhEGFs?
  1. Recombinant human epidermal growth factor (rhEGF) facilitates diverse array of cellular pathways to promote wound healing & tissue recovery.EGF promotes migration, proliferation, cytoprotection, cellular differentiation, collagen synthesis and inhibition of apoptosis. Matrix metalloproteinases (MMPs) are enzymes responsible for collagen & other protein degradation in extracellular matrix (ECM) that is essential for wound re-epithelialization.
1. What is ColGen™ ?
  1. ColGen™ is a sterile collagen sheet commonly used as biological wound dressing.
2. Why Collagen wound dressings?
    Native intact collagen provides a natural scaffold or substrate for new tissue growth. Dressings containing collagen are thought to provide the wound with an alternative collagen source that can be degraded by the high levels of MMPs as a sacrificial substrate, leaving the endogenous native collagen to continue normal wound healing.
    Collagen has been used widely within wound care, and in multiple forms for different reasons. The multiple forms of collagen lend themselves to a variety of wound presentations, making it a favourite among wound specialists.
3. What are the different types of ColGen™ sheets and their indication?
    We have introduced 3 types of ColGen™  sheets, each having a different application.
  1. ColGen™ Matrix –it’s a sterile collagen dry sheet used as biological wound dressing. It is indicated for2nddegree/ Superficial Burns | Skin Donor Sites | Surgical Wounds | Traumatic Wounds(Abrasions, Skin Tears, etc.,) Ulcers - Skin (Chronic), Pressure (Shallow), Venous/Vascular & Diabetic.
  2. ColGen-W™ -It is a collagen sheet preserved in isopropylalcohol and water. Its indications area) 2nddegree, non-infected burns, superficial and deep dermal burns. b) 3rddegree burns - As a temporary cover after escharectomy/ tangential excision Skin donor sites. c) Skin Ulcer (chronic) - Stasis, Arterial or Tropic, Pressure ulcers (shallow) and Leprosy ulcers. d) Dermabrasion - traumatic loss of skin cover. Open fractures - as temporary skin cover.
  3. ColGen-MM™ - Contains primarily a type 1 collagenin lyophilized flakes form along with Topical Mupirocin andMetronidazole of specified volumes.Non-healing ulcers, Diabetic foot ulcers, Pressure ulcers, venous ulcers, Traumatic wounds,Surgical wounds, Infected wounds / burns, minimally to heavily draining wounds.
4. How is the ColGen™ stored ?
  1. All the three types of ColGen™ sheets are stable at room temperature and are sterilized by gamma irradiation.
5. What is the role of collagen in wound healing?
  1. Functionally, Collagen is known for its wound healing properties by aiding cellular activity and providing anorganized matrix in the skin. Provides moisture to the wound bed, preventing dehydration of granulation tissue. Decreases wound surface contamination. Being transparent gel, it facilitates direct monitoring of the wound. Collagen dressing technology helps stimulates new tissue growth, while encouraging autolytic debridement, angiogenesis, and re-epithelialization.
6. What all precautions must be taken while using the different types of ColGen™ sheets?
    Preventive measures to be taken while using the different types of ColGen™ sheets are:
  1. ColGen™ Matrix­–Avoid using sheets on patients who are hypersensitive to Collagen.Grossly infected wounds may reject sheets. Intended for single and external use only.
  2. ColGen-W™ -Avoid using sheets on patients who are hypersensitive to Collagen.Grossly infected wounds may reject sheets. Discard the preserving fluid. Sterility not guaranteed if the pack is damaged or open. For external use only.
  3. ColGen-MM™ -The product is made from bovine source. Do not use if you are allergic to bovine derived materials.Discontinue use of flakes if you experience redness, pain, swelling or blistering and inform your physician without delay.
1. What is PROLYSETM and how is it used ?
  1. PROLYSETM is apapain-urea cream, used for the enzymatic debridement of wound healing that decreases the infection by reducing bacterial load on the wound site. It also increases the granulation epithelialization. In simpler words, PROLYSETM promotes better and quick healing of the wound.
2. What is papain-urea and how it is effective?
  1. Papain is an enzyme derived from the papaya tree (Carica papaya). It is relatively ineffective when used alone as a debriding agent and required the presence of activators to stimulate its digestive potency.But when combined with urea, it acts as a very effective debriding agent.
3. How is the PROLYSETM stored?
  1. PROLYSETM must be stored in a cool and dry place, it is stable at room temperature. Take care that you do not freeze it. It is suggested to close the cap tightly after usage.
4. What all precautions must be taken while using PROLYSETM ?
  1. Not to be used in eyes.
5. What is the indication of PROLYSETM ?
  1. For debridement of necrotic tissue and liquification of slough in acute and chronic lesions such as pressure ulcers, varicose and diabetic ulcers, burns, postoperative wounds, pilonidal cyst wounds, carbuncles and miscellaneous traumatic or infected wounds.
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